Strategies for reducing inappropriate antipsychotic use in long-term care by implementing behavioral and environmental interventions.
A practical, evidence-based guide for reducing inappropriate antipsychotic use in long-term care settings through integrated behavioral and environmental strategies that prioritize person-centered care, staff support, and nonpharmacological approaches to agitation and behavioral challenges.
Published July 16, 2025
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In many long-term care facilities, antipsychotics are used to manage behaviors associated with dementia or mental illness, sometimes without a thorough assessment or ongoing review. This practice raises concerns about safety, effectiveness, and the risk of adverse effects. When residents receive these medications inappropriately, the consequences can include falls, cognitive decline, metabolic complications, and reduced quality of life. A shift toward behavioral and environmental strategies requires commitment from leadership, clear policy guidelines, and a culture that values nonpharmacological care as a first option. By focusing on assessment, alternatives, and monitoring, facilities can begin to reduce reliance on antipsychotics responsibly.
The first step is a comprehensive review of current pharmacologic regimens and documentation. Clinicians should verify indications, confirm that nonpharmacologic strategies have been attempted, and establish a plan for deprescribing where feasible. Regular multidisciplinary rounds are essential, including physicians, nurses, pharmacists, therapists, and family members. These teams can identify symptom triggers, track response to interventions, and determine when a medication can be tapered or discontinued. Documentation should reflect the resident’s goals, preferences, and informed consent. Transparent communication with families helps align expectations and fosters trust, which is crucial when changing entrenched treatment patterns.
Build a sustained, collaborative structure for ongoing deprescribing and care improvement.
Behaviorally informed care in long-term settings involves structured routines, predictable environments, and consistent responses to triggers. Staff can learn to interpret agitation as communication, not defiance, and respond with calm, nonintrusive techniques. Environmental adjustments such as improved lighting, reduced noise, and meaningful activities can decrease agitation. Person-centered activities tailored to each resident’s history and preferences enhance engagement and reduce distress. Training programs should emphasize de-escalation skills, boundary setting, and the use of nonpharmacological comfort measures. By aligning environmental design with individualized care plans, the facility supports safer behavior management while minimizing medication reliance.
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Conversely, environmental interventions also require ongoing evaluation. Regular assessment of scent, noise level, and crowding can reveal how stimuli contribute to challenging behaviors. Scheduling changes—like quiet periods after meals, predictable mealtimes, and structured social opportunities—provide stability. Accessibility to favorite objects, reminiscence corners, and familiar routines fosters a sense of safety. Collaboration with occupational and physical therapists helps adapt activities to functional abilities. When staff see tangible improvements through observations and resident feedback, the rationale for avoiding unnecessary antipsychotics strengthens, and families notice a more humane approach to care.
Integrate regular reviews and pharmacist support with resident-focused deprescribing.
Staff education is a foundational pillar for reducing inappropriate antipsychotic use. Ongoing training should cover pharmacology basics, nonpharmacologic alternatives, and the ethical dimensions of sedation. Educational modules can include case studies, crisis de-escalation drills, and peer coaching. Empowering frontline caregivers to implement behavioral strategies increases confidence and reduces perceived dependence on medications. Importantly, education must be reinforced by supportive supervision, feedback loops, and opportunities for reflection after challenging shifts. When staff feel equipped and supported, they are more willing to try nondrug approaches, document outcomes, and participate in deprescribing plans alongside clinicians.
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Pharmacists play a pivotal role in stewardship within long-term care. They can conduct medication reviews, flag potential drug interactions, and suggest tapering schedules aligned with residents’ goals. Pharmacists collaborate with prescribers to identify alternative therapies for agitation, anxiety, or psychosis, including nonpharmacologic interventions and nutritional optimization. They can also help monitor withdrawal symptoms, ensuring patient safety during dose reductions. Regular audits of antipsychotic use, with feedback to the care team, reinforce best practices. By embedding pharmaceutical expertise into daily rounds, facilities strengthen accountability and create measurable improvements in medication appropriateness.
Implement targeted, proactive strategies to minimize antipsychotic exposure.
Family engagement is essential to the deprescribing journey. Families bring context about personal history, triggers, and meaningful routines that may reduce distress when honored in care plans. Transparent conversations about risks, benefits, and the goals of care help align expectations. Families should be invited to participate in care conferences, contribute to nonpharmacologic strategies, and celebrate successes when agitation declines without medications. Providing education to families about potential withdrawal effects and monitoring responsibilities strengthens partnership. When families witness concrete adjustments—more participation in activities, fewer episodes of aggression, and safer sleep patterns—support for nonpharmacologic care grows.
Nonpharmacologic interventions for behavioral symptoms include individualized activity programs, music and art therapies, reminiscence, and pet-assisted therapies where appropriate. These approaches can reduce agitation and aggression while enriching emotional well-being. Staff should document residents’ responses to different activities, noting which strategies yield the most benefit with the least risk. Sensory integration techniques, such as weighted blankets or tactile stimulation, may be helpful for some residents when used cautiously. Environmental enrichment, social engagement, and meaningful routines together create a supportive ecosystem that diminishes the perceived need for antipsychotics.
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Sustain momentum through ongoing evaluation, education, and leadership.
Behavioral management plans should begin with a thorough assessment of reversible causes. Pain, urinary retention, infection, constipation, or sensory deficits can masquerade as behavioral disturbances. Treating these underlying issues often reduces agitation without drugs. Sleep disturbances, delirium risk, and inadequate hydration must also be addressed. A systematic approach ensures that medications are not chosen as first-line solutions. When nonpharmacologic strategies fail to control severe symptoms, clinicians can consider cautious, monitored pharmacologic steps, prioritizing the lowest effective dose for the shortest duration while pursuing deprescribing as promptly as possible.
Data-driven monitoring supports accountability and progress. Care teams should track rates of antipsychotic prescribing, dose changes, adverse events, and time to deprescribing milestones. Analytics help identify facilities with sustainable improvements and those needing targeted support. Sharing success stories and lessons learned fosters a learning culture that values continuous improvement. Regular performance dashboards, coupled with peer mentoring, keep deprescribing goals visible and actionable. Residents and families benefit from transparent reporting that demonstrates commitment to safe, person-centered care and careful medication use.
Leadership commitment is critical to long-term success. Administrators must allocate resources for staffing, training, and environmental upgrades while maintaining a clear policy that prioritizes nonpharmacologic care. Leadership should champion regular interdisciplinary rounds, deprescribing protocols, and family engagement initiatives. Clear lines of accountability help ensure adherence to guidelines, smooth implementation of changes, and timely addressing of concerns. A culture that celebrates small wins—fewer antipsychotic days, improved resident comfort, and enhanced well-being—motivates teams to persevere. When leaders model values centered on dignity and safety, the entire organization benefits through safer, more compassionate care.
Finally, ongoing research and quality improvement enrich practice. Facilities can participate in learning collaboratives, contribute to registries, and adopt innovative behavioral interventions. Continuous improvement cycles—plan, do, study, act—allow teams to test new strategies, measure outcomes, and refine approaches. Sharing results with staff, residents, and families reinforces trust and engagement. As evidence accumulates around alternatives to antipsychotics, long-term care can evolve toward care models that respect autonomy, protect health, and reduce unnecessary pharmacologic exposure. The path is incremental but meaningful, delivering lasting benefits for residents and care teams alike.
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