Practical approaches to minimize polypharmacy during care transitions to long-term care facilities and nursing homes.
A practical, patient-centered guide to reducing unnecessary medications during transitions into long-term care, detailing evidence-based strategies, stakeholder roles, and actionable steps to improve safety, efficacy, and overall well-being.
Published July 29, 2025
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Transitions into long-term care settings often introduce the risk of polypharmacy, where residents accumulate medications due to fragmented care, multiple prescribers, and incomplete medication histories. Effective strategies begin with comprehensive medication reconciliation conducted by a trained pharmacist or clinician who reviews every current prescription, over-the-counter product, and herbal supplement. The goal is to identify duplicates, contraindications, duplicative therapeutic classes, and changes in organ function that may affect drug choice. Engaging family members and caregivers in the reconciliation process enhances accuracy and adherence, while documenting allergies and past adverse drug events helps prevent repeat errors. A clear, portable list should accompany the patient at admission, during transfers, and after settlement of care plans.
Beyond reconciliation, structured medication review sessions support safer transitions by prioritizing essential therapies and de-prescribing where appropriate. Clinicians should apply criteria such as the Beers or STOPP/START guidelines to flag potentially inappropriate medications in older adults. Decisions should consider the resident’s goals, prognosis, and functional status, not merely disease targets. Deprescribing must be collaborative, with consent from residents or proxies and careful taper plans to minimize withdrawal risks. Providing education about the purpose of each medication empowers residents to participate actively. Coordination with pharmacy services ensures access to generic alternatives and dose adjustments that align with current kidney, liver, and cardiac function.
Structured review and goal-aligned deprescribing reduce treatment burden and harm.
A successful approach engages a multidisciplinary team that includes physicians, pharmacists, nurses, social workers, and family members. Each member contributes unique insights: pharmacists offer drug interaction checks and alternatives, nurses monitor daily symptoms and side effects, and social workers help align medications with the resident’s care goals. Regular team meetings to review new or continuing prescriptions reduce the risk of late changes being overlooked. Structured communication channels, such as standardized transfer summaries and electronic health record prompts, ensure that all parties remain informed across settings. The emphasis remains on minimizing nonessential medications while preserving those essential for symptom control, infection prevention, and stability.
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In practice, initiation of a formal deprescribing protocol during admission can translate into measurable benefits. Start with clarifying the primary diagnoses and determining which medications directly address those conditions. Then identify items without clear indications, those causing adverse effects, or those that may interact poorly with current therapies. A safe taper plan should accompany any cessation, with monitoring for withdrawal symptoms or clinical deterioration. Documentation should reflect the rationale for stopping a drug and the expected timeline for reassessment. With a transparent plan, residents and caregivers gain confidence, and care teams reduce unnecessary complexity in pharmacotherapy that often burdens ongoing management.
Clear communication and patient-centered goals guide optimization.
As facilities receive new residents, establishing a policy-driven framework for medication management becomes crucial. The framework should require accurate medication histories, current indication validation, and explicit ownership of each drug. Access to a centralized medication list that travels with the patient helps prevent duplicate prescriptions and inconsistent dosing. When possible, consolidate drug regimens to simpler schedules, which can improve adherence and reduce confusion for both staff and family. Policies should also address over-the-counter medications and supplements, which commonly interact with prescription drugs. By setting expectations for clinicians to reassess at defined intervals, transitions become negotiating points rather than surprise events.
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Education remains a cornerstone of safe transitions. Families often feel overwhelmed by complex drug regimens, so providers should use plain language to explain why each medication is prescribed and what signs would prompt a review. Training for frontline staff on recognizing adverse drug reactions and understanding basic pharmacology helps catch problems early. Residents benefit from medication cards that summarize drug name, purpose, and potential interactions. Additionally, decision aids can guide conversations about goals of care, ensuring that treatments align with preferences. This collaborative education strengthens trust and supports sustained medication safety after move-in.
Data-driven monitoring and quality improvement sustain safe prescribing.
Transition-specific communication practices help ensure that medication changes are intentional and evidence-based. A transfer summary should include the active medications, last dose, and any planned changes, along with reasons. Pharmacists can send notes highlighting potential drug-drug interactions or renal dosing concerns. When shifts occur—from hospital to nursing home or from one care team to another—timely updates reduce confusion and prevent harmful substitutions. Open dialogue with residents about potential side effects and achievable goals fosters shared decision making. Effective communication also involves documenting when a medication is continued because of symptom management needs, not merely tradition.
Technology-enabled solutions support safer polypharmacy management. The integration of electronic health records with clinical decision support can flag duplicate therapies, contraindications, and dose thresholds appropriate for frail older adults. Automated alerts help clinicians revisit medications during daily rounds or weekly reviews. Telepharmacy services may deliver expert input to facilities lacking on-site pharmacists, enhancing oversight of complex regimens. Audit trails track changes and outcomes, enabling continuous quality improvement. In the long term, data from transitions can reveal patterns, informing policy refinements and staff training priorities that sustain safer prescribing environments.
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Ongoing evaluation ensures care plans stay aligned with patient needs.
Practical steps at admission begin with a door-to-door medication inventory that includes all prescriptions, vitamins, and supplements. The inventory should capture dosage, route, frequency, and last fill date, along with any known allergies. Clinicians should compare this list to diagnoses, functional status, and risk factors such as falls or delirium. Any discrepancies should prompt immediate clarification with the prescribing clinician or the patient’s family. A risk stratification approach helps allocate pharmacist time where it is most needed, prioritizing high-risk residents for urgent reconciliation and in-depth review. By documenting the alignment between prescribed therapies and goals of care, facilities create a coherent rationale for ongoing treatment decisions.
Post-admission follow-up is essential to sustain progress. Scheduling a medication review within the first week allows for timely adjustments as the resident’s condition stabilizes. During this review, clinicians reevaluate the continuation of chronic therapies and assess newly initiated drugs. Any new adverse events or interactions should trigger a rapid re-assessment, with the aim of returning to a leaner, more appropriate regimen whenever possible. Ongoing communication with family members ensures they understand changes and can monitor for symptom shifts. A transparent process reduces anxiety and helps residents feel heard during a vulnerable transition period.
Long-term success depends on repeated, structured reassessment of each resident’s pharmacotherapy. Clinicians should schedule periodic medication reviews that reassess indications, risks, and patient preferences. The goal is to maintain a stable regimen that minimizes adverse events without compromising symptom relief or disease control. Regularly updating the medication list in the patient’s chart helps prevent drift toward unnecessary complexity. Additionally, facilities can implement performance indicators such as rates of deprescribing, adverse drug events, and hospital readmissions related to medication issues. Tracking these metrics enables targeted improvements and accountability across the care team.
Finally, empowering residents and families to be partners in deprescribing sustains safer care transitions. Sharing decision-making responsibilities reinforces trust and improves adherence to revised regimens. Providing accessible materials that explain medication purposes and potential risks supports informed choices. Encouraging questions and offering decision aids helps residents articulate their priorities. When goals change, prompt recalibration of the regimen preserves quality of life. A culture that values patient safety, transparent communication, and continual learning is the strongest defense against polypharmacy during transitions into long-term care settings.
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